Dimer ?? białka G - cząsteczka sygnałowa

Abstrakt

Summary The extracellular signals received by receptors with seven membrane-spanning regions that activate the G proteins, are routed to several distinct intracellular pathways. The G proteins consist of two functional units, G? subunit, that binds guanine nucleotides and G?? dimer that functions as a single unit. The regulation of signal transduction by the G?? complex at different protein interfaces: subunit - subunit, receptor - G protein, and G?? - effector, are reviewed. G?? dimer regulates over twelve cellular effectors including phospholipase-?, adenyl cyclases, ion channels and G-protein coupled receptor kinases, which control a broad range of cellular processes.